Category Archives: Medicine

BOOK: “The Mind Electric” by Pria Anand

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The Mind Electric: A Neurologist on the Strangeness and Wonder of Our BrainsThe Mind Electric: A Neurologist on the Strangeness and Wonder of Our Brains by Pria Anand
My rating: 5 of 5 stars

Publisher Site — Simon & Schuster

There are A LOT of pop neuroscience books out there that reflect upon what we know about the brain from what goes wrong with it. I thought I was done reading such books because, while the first few are fascinating, they tend to retell the same stories.

That said, I’m glad I read this one, and what made it worth reading was that the science was explored in a very personal way, and I don’t just mean that the author recited her own personal experiences or those of her patients (though she does both,) but rather that the whole book is imbued with her worldview. She relates maladies of the mind to works of literature, of Greek and Hindu mythology, and to other aspects of culture in a relatable manner.

Another factor that sets this book apart is that its author shows a passion for language. In that sense, it reminded me of the works of Oliver Sacks (who she references a number of times,) rather than your average — articulate but linguistically conservative — neuroscientist.

I’d recommend this book for any readers interested in neuroscience, particularly anyone looking for a book that sets itself apart from the crowd. (I don’t recall it even mentioning Phineas Gage, which I thought was a requirement of all such books.)

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PROMPT: Profession

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Daily writing prompt
What profession do you admire most and why?
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Nurse. I think it takes a tremendous level of humility and compassion. Also, I suspect it may be among the last handful of human jobs (as we know them now) to still exist once AI-robots start doing pretty much all productive tasks better, faster, and more efficiently than humans. I think long after our doctors are machines, we will have human nurses.

BOOKS: “Lost in the Twentieth Century” by Albert Szent-Györgyi

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Lost in the Twentieth Century (Annual Review of Biochemistry Book 32)Lost in the Twentieth Century by Albert Szent-Györgyi
My rating: 5 of 5 stars

Available Online – NIH National Library of Medicine

This is the very brief autobiography of a fascinating man. Szent-Györgyi is most famous for work in biochemistry involving Vitamin C, work that won him a Nobel Prize. However, his life is not only notable for science before and after the Nobel (after he worked on the physiology of muscular activity, on electron activity in physiology, and on cancer.) He also performed important works outside the laboratory, notably he conducted an espionage / diplomatic mission during the Second World War (“Espionage” in that he traveled to Turkey under false pretenses, under cover of giving a lecture at a university, “diplomatic” in that the trip’s true objective was to negotiate with the Allied powers.)

Szent-Györgyi has some interesting quips and insights that make it worth reading this pamphlet-scale book, even though his Wikipedia page probably contains as much information. He had an interesting way of thinking about matters, both scientific and not, and was politically and socially engaged in the world.

If you’re curious about Szent-Györgyi or enjoy biographies, in general, I’d highly recommend reading this one.

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“Surgeons must be very careful” (156) by Emily Dickinson [w/ Audio]

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Surgeons must be very careful
   When they take the knife!
 Underneath their fine incisions
   Stirs the Culprit -- Life!

PROMPT: Invention of a Lifetime

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Daily writing prompt
The most important invention in your lifetime is…
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If “most important” means having both a broad and profound societal impact, then the answer would have to be the internet. [Though I learned through said internet that Arpanet was already operating before I was born. So, if you consider the internet to be a simple progression of Arpanet, then my answer would be a lie.]

If “most important” means having the greatest benefit to mankind in terms of improved quality of life or lifespan, then it’s probably some medicine. Which one? I have no idea. [Maybe that breakthrough that both won the Nobel and made it much easier and quicker to get the COVID vaccines out (mRNA translation, or whatever it was called.)]

PROMPT: Longevity

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What are your thoughts on the concept of living a very long life?

As long as I’m of sound mind and capable body, I’m fine with it, but not at any cost. I’d rather shuffle off this mortal coil than drag out the suffering of immobility and / or dementia.

I think Atul Gawande’s “Being Mortal” is good required reading. Among other things, he talks about the smoke and mirrors of our species’s increased lifespan. (i.e. increased lifespan, yes, but too often at the cost of diminished quality of life through those additional years.)

PROMPT: Surgery

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Daily writing prompt
Have you ever had surgery? What for?
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Tonsillectomy; age 4. A couple others that I’m not sure constitute surgery (e.g. wisdom-teeth removal.)

The Yetis’ Reply [Limerick]

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A grouchy nitwit wrote a polemic
about how Yetis had caused the Pandemic.
The Yetis protested,
and kindly requested
the man ponder head-in-ass hygienics.

BOOK REVIEW: Introducing Epigenetics by Cath Ennis

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Introducing Epigenetics: A Graphic Guide (Introducing...)Introducing Epigenetics: A Graphic Guide by Cath Ennis
My rating: 4 of 5 stars

Amazon.in Page

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I’m old enough to remember when the human gene sequence was first being decoded, and there was a widespread belief that it was going to end genetic diseases in one fell swoop. It didn’t do that, and – in fact – seemed to result in whole new levels of confusion. It’s fascinating to me that now Epigenetics, a subject that grew out of that confusion, is also being seen as the ticket to ending disease. Epigenetics investigates what traits are expressed and why, given that a specific gene sequence has a vast array of potential for various traits to be (or not to be) expressed.

For those familiar with this series (the “A Graphic Guide” series,) this book is more difficult to digest than most titles, certainly than any of the several others that I’ve read. To be fair, the subject matter is more technical than most, leading to it being more jargon- and acronym-intensive. In addition, the subject isn’t cut up into as small of pieces as most of the books. This one has far fewer and longer chapters than the others that I’ve read.

That said, while it reads technically for the general reader, there are a few concepts (methylation, demethylation, and histone modification) that are frequently revisited throughout the book, and so one can get a basic grasp of those concepts. The book also explores some issues that are more readily understood by the lay reader, such as: nature v. nurture in gene expression, the role of twin studies, and how pseudo-scientific individuals and organizations have made fraudulent claims involving Epigenetics.

If you want to learn about the fundamentals of Epigenetics, you may want to look into this book — but keep in mind that it’s not a smooth read.

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BOOK REVIEW: The Exquisite Machine by Sian E. Harding

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The Exquisite Machine: The New Science of the HeartThe Exquisite Machine: The New Science of the Heart by Sian E. Harding
My rating: 5 of 5 stars

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Release date: September 20, 2022

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In this book, a renowned heart researcher presents an overview of what we know (and don’t know) about the human heart: i.e. what can go wrong with it and why, how [and to what degree] it fixes itself, and what modern medicine can do to treat or replace a damaged heart. I learned the most from the middle of the book – i.e. chapters five through seven. Chapter five explores plasticity in the heart, plasticity is a concept that most people associate with the brain and its ability to rewire itself to contend with damage or changing needs. The other two chapters look at how the heart can be damaged, specifically as a result of emotional experience. A “broken heart” isn’t necessarily a misnomer.

Chapter four is also intriguing but takes the win for “which one of these things is not like the others.” It deals with big data, though not in a general sense but rather as it applies to gaining a better understanding of the heart. This chapter discusses a common challenge of medical research: that it’s hard to come up with large enough study groups of patients with close enough to the same problem to draw solid conclusions. Four also discusses the potential of the vast amount of data that exists, e.g. Fitbit heart rate figures.

The last couple chapters deal largely with the future of heart repair through genetic / biological means (as opposed to via mechanical hearts and technologies, which are dealt with in Chapter nine.) This is where the book gets to be a challenging read for a readership of non-experts. It gets technical and jargon- / acronym-heavy.

The heart is an astounding entity, relentlessly at work, rarely giving up despite regularly being subjected to intense shocks, an organ tied to our whole being in a way that humans have always felt – if only just begun to understand. If you’re interested in learning more about this magnificent organ, check this book out.

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