BOOK REVIEW: Introducing Epigenetics by Cath Ennis

Introducing Epigenetics: A Graphic Guide (Introducing...)Introducing Epigenetics: A Graphic Guide by Cath Ennis
My rating: 4 of 5 stars Page

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I’m old enough to remember when the human gene sequence was first being decoded, and there was a widespread belief that it was going to end genetic diseases in one fell swoop. It didn’t do that, and – in fact – seemed to result in whole new levels of confusion. It’s fascinating to me that now Epigenetics, a subject that grew out of that confusion, is also being seen as the ticket to ending disease. Epigenetics investigates what traits are expressed and why, given that a specific gene sequence has a vast array of potential for various traits to be (or not to be) expressed.

For those familiar with this series (the “A Graphic Guide” series,) this book is more difficult to digest than most titles, certainly than any of the several others that I’ve read. To be fair, the subject matter is more technical than most, leading to it being more jargon- and acronym-intensive. In addition, the subject isn’t cut up into as small of pieces as most of the books. This one has far fewer and longer chapters than the others that I’ve read.

That said, while it reads technically for the general reader, there are a few concepts (methylation, demethylation, and histone modification) that are frequently revisited throughout the book, and so one can get a basic grasp of those concepts. The book also explores some issues that are more readily understood by the lay reader, such as: nature v. nurture in gene expression, the role of twin studies, and how pseudo-scientific individuals and organizations have made fraudulent claims involving Epigenetics.

If you want to learn about the fundamentals of Epigenetics, you may want to look into this book — but keep in mind that it’s not a smooth read.

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BOOK REVIEW: Philosophy of Biology: A Very Short Introduction by Samir Okasha

Philosophy of Biology: A Very Short IntroductionPhilosophy of Biology: A Very Short Introduction by Samir Okasha
My rating: 4 of 5 stars Page

Excepting the final chapter, this wasn’t the book I expected, but it did raise some compelling questions. The book did devote more space to semantic and categorical questions than I found useful or interesting. These are the kinds of questions which philosophers may find joy in catching peers in paradoxes, but which are pure navel-gazing, offering no insights on how to achieve the well-lived life or to better understand the grand questions of the universe.

The book looks at the metaphysical and epistemological ramifications of evolution, species classification, genetic and memetic transmission, and the degree to which humans are or aren’t constrained by our evolutionary history. Among the questions I found most interesting were: Is it useful to speak in terms of “function” (i.e. “what a thing is for”) when discussing biological entities, given that those words seem to imply an intended purpose inconsistent with evolution? Does selection occur at the level of the individual, the group, or both? How does one reconcile the Mendelian notion of a “gene” with that of molecular biology? Lest one think Mendel’s ideas were partially formed and are now supplanted, they do internally explain dominance and recessivity, a thing molecular biology can’t yet do. Is it reasonable to apply the logic of evolution and heritability to the cultural domain?

I got a lot out of this tiny guide. It may have spent more time on semantics and categorization than I would have liked (as well as more time reviewing basic biological science,) but it did raise some intriguing questions that I didn’t anticipate as well as illuminating new dimensions of those I did. Your patience with the insubstantial questions will be a major factor in how much you get out of this book.

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