Category Archives: science

BOOK REVIEW: The Psychobiotic Revolution by Scott C. Anderson, et. al.

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The Psychobiotic Revolution: Mood, Food, and the New Science of the Gut-Brain ConnectionThe Psychobiotic Revolution: Mood, Food, and the New Science of the Gut-Brain Connection by Scott C. Anderson
My rating: 5 of 5 stars

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For centuries there have been cases in which a change in diet –often accidental– led to relief from a mental illness. However, given the sporadic nature of such effects and the complete lack of understanding of microbes, the enteric nervous system (i.e. the gut’s own “brain” that communicates with — but is also autonomous of — our “first” brain,) and the complexity the symbiotic relationships involved, these anecdotal cases had limited influence on the state of medicine. However, recent years have seen an explosion of understanding in this domain. This has resulted in a vast number of books being written on the role of microbes in the gut for overall health, the role that changing diet can have on changing our microbiota, and related topics such as how the overuse of antibiotics can have a deleterious effect on health by tossing out the microbial baby with the bath water. This book touches on all those topics (and more) as it explores the role of our bacterial hangers-on on our mental health.

The book consists of nine chapters. The chapters are organized so as to first present one with the necessary background to understand how changes to one’s gut microbiota can improve one’s health —particularly one’s mental health (though many of the mental illnesses influenced by microbiota are linked to physical ailments)— before moving on to the specifics of what microbes have been shown to have a given effect and what diseases can be influenced by consumption of probiotics.

The first five chapters give the reader an introduction to the topic and an overview of information one needs to know to understand the later chapters. Chapter three gives one an overview of the changing profile of one’s microbiota over the course of one’s life. Particular emphasis is given to one’s youth and to the transfer of bacteria to infants. [Readers may be aware of the problem that c-section births result in a failure of babies to receive a dose of beneficial microbes imparted by passage through the vaginal canal.] Chapter four takes one on a quick ride through one’s alimentary canal from mouth to rectum, with particular emphasis on questions such as how bacteria survive the stomach’s acid bath, and which parts of the digestive system contain which microbes (and to what effect.)

The last four chapters dig deeper into the specifics. These chapters look at specific probiotics, how one can get them into one’s system, and what science has found out about probiotics and psychobiotics (like probiotics, but specifically ones that influence mood and mental states) effects on specific ailments. Chapter eight, which deals with major diseases, does cover physical ailments as well as mental ones because – as mentioned— these afflictions often go hand-in-hand. The last chapter (Ch. 9) looks at where this body of knowledge is going. It delves into practices that are presently well-established, such as fecal matter transplants, but also into challenging works-in-progress such as attempts to develop narrower spectrum antibiotics so that we can get the life-saving benefits of these medications without their crippling side-effects.

The book has many graphics, as one would expect from a work that investigates such a complex scientific topic. I can’t really speak to the quality of the graphics as the review copy I read didn’t have completed graphics. However, the subjects of the graphics seemed appropriate and well-placed. The book also has a glossary, annotations, and a further reading section to assist the reader in the study of this subject.

I found this book to be informative and engaging, and would highly recommend it for anyone interested in the role of microbiota on mental health. The text was well-organized and readable. Given the scientific nature of the material, it’s easy for such a book to become ponderous, but the authors made attempts to keep the tone light and the presentation non-intimidating.

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5 Fascinating Nonfiction Books I Read in 2017

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NOTE: I already did a post of the books published in 2017 that had the most profound effect on me. That post can be seen here. This one is about books I read in 2017, most of which weren’t published this year. The hyperlinks go to my GoodReads review of the respective book.

 

5.) Narconomics by Tom Wainwright: This is a look at how drug cartels have been drawing from the playbooks of successful multinational corporations to make their operations more efficient and profitable. It contains gripping journalism and–for an economics wonk such as myself–it hits the spot with regards to scholarly curiosity as well.

 

4.) The Man Who Wasn’t There by Anil Ananthaswamy: Neuroscience has been converging on a conclusion drawn by Buddhists long ago (though not necessarily sharing identical explanations /mechanisms) that the self is an illusion. Ananthaswamy considers the neuroscience of self by examining how nervous system ailments and injuries have challenged common explanations about what the self is based on what it feels to be a self. (e.g. Out-of-body experiences can be induced with electrodes. Some people deeply feel they are dead, or that they either have limbs that aren’t present or that limbs that are don’t belong to them.)

 

3.) The Way of the Iceman  by Wim Hof and Koen De Jong: Any book that can get one to start taking cold showers has to be pretty persuasive. Wim Hof is known for his cold endurance “stunts,” but his argument in this book is that anyone can do it and that there are health benefits to doing so. The authors report on the science of said benefits as well as offering a program to start one’s way on such a program.

 

2.) Trying Not to Try by Edward Slingerland: Slingerland brings a fresh look at the ancient Chinese concept of wu-wei (apparently pronounced “ooo-way.”) Wu-wei is variously translated as “actionless action” or “to do without doing,” and–while that may sound like meaningless bumper-sticker wisdom–it reflects a state of effortless action that requires an elusive but powerful state of mind.  Slingerland presents varied Taoist and Confucian approaches to the subject, but also relates the idea to modern ideas such as Mihaly Csikszentmihalyi’s “Flow.”

 

1.) How Enlightenment Changes Your Brain by Andrew Newberg and Mark Waldman: A neuroscientist and a positive psychologist team up to explain the common routes to the enlightened states of mind described in both Eastern religious / spiritual traditions and the mystic branches of Western religions (i.e. Jewish Kabbalah, mystic Christian sects, and Sufi Islam,) as well as their scientific underpinnings.

5 Books to Introduce You to Your Gut Microbiota

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5.) The Wild Life of Our Bodies by Rob Dunn: This book takes a broad look at the role that hangers-on have on  human life.

 

4.) The Psychobiotic Revolution by Scott C. Anderson et. al.: This book focuses on the role that our gut microbiota have on our mental well-being–which increasingly appears to be substantial.

 

3.) Missing Microbes by Martin J. Blaser: The focus of this book is on how our love of antibiotics in every form– from pills to antimicrobial soaps–is killing us by denying us microbiotic diversity and robustness.

 

2.) 10% Human by Alanna Collen: Collen’s book addresses many of the same issues as the other books mentioned, but–as the title suggests–it emphasizes the fact that a human has 10 times as many hangers-on of other species as it does cells that are contiguous to the body. (If you’re wondering how this could be, it’s because the human body has some pretty big cells [some macroscopic, in fact] and the bacteria and other single-celled species tend to be relatively tiny.)

 

1.) I Contain Multitudes by Ed Young: This is probably the most highly-regarded of the books on this subject. It was considered one of the best science books of 2016.

5 Essential [and Sometimes Hilarious] TED Talks About the Human Body

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5.) 3 Clues to Understanding your Brain by VS Ramachandran: Ramachandran discusses three afflictions that offer insight into the working of the brain. Capgras Syndrome occurs when individuals think loved ones have been replaced by impostors. Phantom limbs occur when there is an amputated limb which the brain continues to feel the presence of. Synesthesia is a muddling of sensory inputs /experiences.





4.) Charming Bowels by Giulia Enders: How we poop. How our gut nervous system influences our central nervous system. Why there is such a thing as “too clean for your own good.”





3.) Can We Create New Senses for Humans by David Eagleman: Our senses are narrowly attuned to taking in that information that offered evolutionary advantage to our ancestors. How might technology help us transcend those bounds?





2.) 10 Things You Don’t Know about Orgasm by Mary Roach: Eyebrow orgasm, thought-induced orgasm, orgasm among the deceased, and how orgasm may cure your hiccups.





1.) The Biology of Our Best and Worst Selves by Robert Sapolsky: Sapolsky explains that one can’t look at one biological system to understand violence or cooperation. Instead, genetics, environment, our nervous system, our endocrine system, and even the digestive system come into play. He also considers how we change.

BOOK REVIEW: Caesar’s Last Breath by Sam Kean

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Caesar's Last Breath: Decoding the Secrets of the Air Around UsCaesar’s Last Breath: Decoding the Secrets of the Air Around Us by Sam Kean
My rating: 5 of 5 stars

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A book about air and the gas molecules that float about in it may not sound gripping. However, Sam Kean has a gift for finding interesting little stories to make talk of nitrogen-fixing, the discovery of oxygen, and the improvement of the steam engine fascinating. Such stories include that of a vaporized resident of Mount St. Helens, a gas-belching lake that suffocated families in their sleep (not a horror movie plot—a documented event), the scientist who both made millions of new lives possible through his nitrogen-fixing process and then took killing to its most despicable with poison gas, the pig who survived nuclear fallout, and, of course, how the last breath of a Roman Emperor came to be his last–and how likely it is that you’re breathing some of it right now. Along the way you’ll learn about farts, about the use of nitrous oxide for fun and surgery, about Einstein’s venture into refrigerator design, about lighter-than-air air travel, and about what air might look like on another planet.

The book is divided into three parts and nine chapters. There are also eight “interludes” that each takes up an intriguing subject that is chemically or topically related to the preceding chapter. The first part, and its three chapters, addresses the components of air and where they come from. The three chapters explore sulfur dioxide and hydrogen sulfide as molecules released by geological processes (e.g. volcanoes,) the abundant but—without great effort—useless element of nitrogen, and oxygen—useful for breathing and setting the world on fire.

The middle part deals with how humans have used components of air for our own purposes. These three chapters discuss nitrous oxide’s invention, the exploitation of steam to power the Industrial Revolution, and the use of lighter-than-air elements for air travel.

The final part both describes ways in which humanity has changed the air, and looks at what we might have to contend with if we need to go to another planet to live. The seventh chapter explores nuclear testing and the radioactive isotopes that have been spread by it. The penultimate chapter examines the ways in which humans have tried to make weather more predictable by engineering it—usually with little to no effect. The last chapter is about what air might look like on other planets, be they planets on which we’d have to make air or ones that already have their own atmospheres.

There are a number of graphics, including molecule diagrams, photos, and artworks. There are also notes and a works cited section.

I’d highly recommend this book. I found it to be fun to read and fascinating. If you’re into science, you’ll love it, and—if you’re not—you may change your mind.

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5 Essential TED Talks on Consciousness

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5.) Anil Seth: Your Brain Hallucinates Your Conscious Reality




4.) David Chalmers: How Do You Explain consciousness?





3.) Max Tegmark: Consciousness is a Mathematical Pattern





2.) Antonio Damasio: The Quest to Understand Consciousness





1.) Oliver Sacks: What Hallucination Reveals about Our Minds

5 Ways the World May Be Weirder Than It Seems

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Werner Heisenberg famously said, “Not only is the Universe stranger than we think, it is stranger than we can think.”



5.) Ancestor Simulation: The idea that we could be in a simulation isn’t only a staple of science fiction–e.g. The Matrix. It’s been given serious thought by thinkers who aren’t exactly on the lunatic fringe–most famously inventor /entrepreneur Elon Musk. The core of the argument goes like this. 1.) We are getting better and better at making simulations ourselves. 2.) At some point we will achieve a simulation indistinguishable from reality. 3.) If 2 is true, then it’s vastly more likely that we are already simulations because if it can be done, it probably already has been done many times over. (Thus, we’re more likely to be in one of the simulations than so-called “base reality.”)



4.) Mathematical Universe Hypothesis: Max Tegmark proposes that the universe may be–at its core–a mathematical structure, making us self-aware substructures. This may sound like a different way of stating the preceding hypothesis, but not necessarily. The simulation hypothesis suggests certain motivations of a simulation creator. MUH doesn’t require a creator or an objective. It could be the nature of reality at it’s most basic.



3.) A Holographic Universe: This idea sprang from thinking about what happens to the information when something falls into a black hole. The idea being that the information is trapped on the outside of the event horizon–i.e. information for a three dimensional entity stored in two dimensions. As physicists pondered this, some concluded that it might be that we are a projection of data, or–alternatively–much of what we see when we look out into space is.



2.) One of Myriad Universes: The idea that our universe is one of many (or an infinite number of) universes comes in several flavors and is a prediction of several theories widely given credence. In some versions, all the universes have different sets of laws and constants such that many flash in and out of existence and only a small proportion are capable of hosting life (but the math of infinity is weird and a small proportion of the infinite may also be infinite. I don’t know, I’m not a mathematician and the infinite never mattered in economics because ground zero is that everything is limited but desires.) This answers the Goldilocks zone issue nicely–i.e. we couldn’t exist if the equations and constants that govern our universe were very much different, but if there are many universes with many sets of laws then we just happen to be in one of the ones we can be in–hence, credulity remains unstrained. Other versions propose universes with the same laws such that there could be an infinite number of you living out lives that may be slightly different than yours (or–for that matter–in which you might be the Supreme Galactic Overlord.)



1.) Time is slowing: A couple Spanish physicists have suggested that the universe might not be expanding at an accelerating rate (as is the consensus view in physics,) but rather time may be slowing. This slowing would be anticipated to continue until one final moment is captured frozen in time–note: said point would be long after the Sun swallows the Earth.

BOOK REVIEW: Supernormal by Dean Radin

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Supernormal: Science, Yoga and the Evidence for Extraordinary Psychic AbilitiesSupernormal: Science, Yoga and the Evidence for Extraordinary Psychic Abilities by Dean Radin
My rating: 4 of 5 stars

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With this controversial book, Dean Radin presents the scientific evidence for an array of psychic powers, but he frames the discussion in terms of yogic siddhis. “Siddhi” is a Sanskrit term for an ability that isn’t seen among the general population–at least not reliably so– and for the most part these “accomplishments” correspond to the categories discussed in parapsychology (i.e. telepathy, precognition, psychokinesis, and clairvoyance.) [Note: As mentioned, this is a controversial book. I will attempt to provide as unbiased a review as possible. I am generally skeptical, but don’t believe in poo-pooing the study of subjects because they offend my skeptical sensibilities. Furthermore, I try to keep an open mind because: 1.) there is no scientific consensus about what consciousness is or how it works, 2.) quantum biology is a subject in its infancy and we may yet learn there is more quantum “spookiness” going on in the brain than we think. 3.) for all I know we are in an simulation and then it’s all a matter of programming.]

The yogic emphasis doesn’t change the book much from the pop psych literature review of parapsychology studies it would otherwise be, except to necessitate background information on yoga and siddhis. However, this emphasis may or may not have opened up a huge additional readership. Outside of a fringe, siddhis aren’t much in vogue among yoga practitioners these days. Among modern day yogis and yoginis, there are some who believe in them and some who think they’re throwbacks to an era of superstition, malnutrition, and wishful thinking. However, even among the former, siddhis are generally considered a distraction. The advice of most of the great yogis has been to not get lost in the pursuit of such powers because chasing siddhis can derail one from one’s ultimate objective (e.g. liberation.) Still, if even a small fraction of yoga practitioners take an interest, that’s a fairly large readership.

So what exactly is the controversy? Obviously, there are many divergent demographics with differing views on the topic. For hardcore skeptics, parapsychology is right up there with alien abduction, bigfoot /yeti sightings, and the anatomy of the Loch Ness monster with respect to being a legitimate topic for scientific study. On the other hand, there are believers who are offended by the mere notion of studying such phenomena with science, and who say such investigations are an assault on their beliefs.

But that’s not a very interesting controversy—i.e. there are some people who won’t believe in such abilities no matter what the evidence, and others who will believe in them no matter what science has to say. So let’s chop off the hardcore skeptics and hardcore believers and ask what the controversy is as it pertains to those of us who consider evidence when drawing conclusions.

The root of the controversy can be stated rather quickly and clearly. Here it is: the effect size is small but statistically significant. What does that mean? Say this study asks a subject to determine which of five randomly selected shapes has been chosen using nothing but his / her mind. Using pure guessing, one would expect to be right 20% (i.e. 1/5th) of the time. If a person happened to get 32% right in a given trial, that means nothing because small samples don’t give one a convergence towards a mean value. (i.e. Intuitively, you know that if you flip a coin 10 times and get 7 heads, it doesn’t necessarily mean anything. If you repeat that 10-flip set 10,000 times, and still get 70% heads, then you probably have a trick coin or something else odd is going on.) So the issue is that even when experimenters repeat the experiment over and over again such that the average value should converge on 20%, it doesn’t. It stays at, say, 30% (exact effects vary but it’s on this order.)

At this point the reader might be thinking of all the factors that could result in this effect (i.e. cheating [insider or outsider], subconscious observation of facial expressions, random selection that is biased, etc.) Well, so have the scientists. In any study, one wants to account for alternative explanations to the utmost. Over the years, researchers like Radin have put all manner of protections in place from quantum random number generators to booths with extreme sound-proofing and Faraday cages (prevents radio signals from transiting.) Still they get this small positive effect that can’t be explained by alternative explanations.

There is also the issue of the filing drawer problem, which Radin devotes considerable space to discussing. It’s the idea that when drawing conclusions from many similar studies, one must accept that there may be many unpublished studies that sit in file drawers because they didn’t produced negative results. These filed / unpublished studies could negate the outcome of the body of studies of that nature. While this remains an open criticism, there is mathematics for determining how many negative studies would have to be turned up to make the results insignificant. Radin argues that the numbers calculated strain credulity.

So this “small but statistically significant effect” is generally agreed upon by all, excepting conspiracy theorists. Now we get to the controversy, which is how to explain this effect. Skeptics run the gamut from hot-blooded haters who claim that it’s all just a scam perpetrated by hoaxers with tenure, to more diplomatic challengers who provide thoughtful, plausible, and non-nefarious explanations for what they believe are false results. Said objections include file drawer problems, statistical “crud factor” (an observed effect in which large sample size studies can show a significant correlations between any two random variables—i.e. everything is correlated with everything else to some degree), and outlier effects.

The latter is a particularly revealing controversy. Say your study results in this 30% instead of 20% effect, and there’s one subject in the study who (over many trials) got the shape right 80% of the time. If you’re a skeptic, you call that an outlier and you want to cut it out of the study because it may be causing part, most, or all of the effect you see. Your assumption is that that this outlier could be anything from a data entry error to an outright cheater, but it’s obviously not a gifted psychic. If you’re a believer, not only do you want to keep that result, you want to find that person and study them to find out if the result was a one-time fluke, or if you have some rare, gifted person.

The book is arranged into three parts. The first part offers background on yoga and siddhis. The second part is the heart of the book and it presents an overview of results from studies of precognition, telepathy, psychokinesis (both of animate and inanimate objects), clairvoyance, and the effect of meditation on these abilities (which also shows a small positive effect, i.e. the general population outdoes probability by a little bit and experienced meditators outperform the general population by a little bit.) The last section is just a couple chapters about the future of parapsychology.

I found this book to be interesting and thought-provoking. Radin comes across as a reasonable investigator who is willing to accept that there is a lot of duplicity going on out in the world, but yet when one uses the methods of science one obtains results that would be generally accepted as successful across the social sciences. At times he does go on anti-skeptic rants. On the other hand, one can imagine his frustration in dealing with individuals unwilling to pin down how much higher the bar must be for parapsychology results over results in more mainstream topics. I think Radin’s greatest mistake was in discussing levitation. Besides at a quantum level, the effects of gravity are well-understood and non-negotiable. While our lack of understanding of consciousness leaves wiggle room to at least consider some unusual happenings, levitation seems a non-starter. Fortunately, as it hasn’t been studied, Radin just presents a couple historical anecdotes and moves on (while—to be fair–acknowledging the fundamental risk in relying on anecdotes.)

I’d recommend this book. I can’t say it swayed my belief on the topic, which tends skeptical, but it did inform my confusion. (It should be pointed out that not all these abilities are equally reviled by science. Precognition is the most fundamentally opposed because it seems to violate the fundamental cause and effect nature of the universe at our scale and larger [as opposed to the quantum level were all sorts of weird happenings transpire.]) I do agree with Radin that there shouldn’t be taboos in science in which scientists are afraid to study a subject of interest because the prevailing notion is that it probably doesn’t have merit. If there weren’t scientists with the cojones to study “crazy stuff” we’d no doubt be far behind our current understanding of the world.

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BOOK REVIEW: Our Mathematical Universe by Max Tegmark

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Our Mathematical Universe: My Quest for the Ultimate Nature of RealityOur Mathematical Universe: My Quest for the Ultimate Nature of Reality by Max Tegmark
My rating: 4 of 5 stars

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In this book, physicist Max Tegmark makes an argument for the possibility of a reality in which the universe is a mathematical structure a theory that predicts a Level IV multiverse (i.e. one in which various universes all have different physical laws and aren’t spread out across one infinite space [i.e. not “side-by-side.”]) Nobel Laureate Eugene Wigner wrote a famous paper entitled, “The Unreasonable Effectiveness of Mathematics in the Natural Sciences.” The article describes one of the great mysteries of science, namely, how come mathematics describes our universe so well and with such high precision. Tegmark’s answer is because the universe is fundamentally mathematical—or at least he suspects it could be.

The first chapter serves as an introduction, setting the stage by considering the core question with which the book is concerned, “What is reality?” The book then proceeds in three parts. The first, Chapters 2 through 6, discuss the universe at the scale of the cosmos. Chapters two and three consider space and time and answer such questions as how big is the universe and where did everything come from. Chapter 4 explores many examples of mathematics’ “unreasonable effectiveness” in explaining our universe with respect to expansion and background radiation and the like (a more extensive discussion is in Ch. 10.) The fifth chapter investigates the big bang and our universe’s inflation. The last chapter in part one introduces the idea of multiverses and how the idea of multiple universes acts as an alternative explanation to prevailing notions in quantum physics (e.g. collapsing wave functions)—and, specifically, Tegmark describes the details of the first two of four models of the multiverse (i.e. the ones in which parallel universes are out there spread out across and infinite space), leaving the other two for the latter parts of the book.

Part two takes readers from the cosmological scale to the quantum scale, reflecting upon the nature of reality at the smallest scales—i.e. where the world gets weird. Chapter 7 is entitled “Cosmic Legos” and, as such, it describes the building blocks of our world as well as the oddities, anomalies, and counter-intuitive characteristics of the quantum realm. Chapter 8 brings in the Level III approach to multiverses and explains how it negates the need for waveform collapse that mainstream physics requires we accept (i.e. instead of a random outcome upon observation, both [or multiple] outcomes transpire as universes split.)

The final part is where Tegmark dives into his own theory. The first two parts having outlined what we know about the universe, and some of the major remaining mysteries left unexplained or unsubstantiated by current theories, Tegmark now makes his argument for why the Mathematical Universe Hypothesis (MUH) is at least as effective at explaining reality as any out there, and how it might eliminate some daunting mysteries.

Chapter 9 goes back to the topic of the first chapter, namely the nature of reality and the differences between our subjective internal reality, objective external reality, and a middling consensus reality. Chapter 10 also elaborates on the nature of reality, but this time by exploring mathematical and physical reality. Here he elaborates on how the universe behaves mathematically and explains the nature of mathematical structures—which is important as he is arguing the universe and everything in it may be one. Chapter 11 is entitled, “Is Time and Illusion?” and it proposes there is a block of space-time and our experience of time is an artifact of how we ride our world lines through it—in this view we are braids in space-time of the most complex kind observed. A lot of this chapter is about what we are and are not. Chapter 12 explains the Level IV multiverse (different laws for each universe) and what it does for us that the others do not. Chapter 13 is a bit different. It describes how we might destroy ourselves or die out, but that, it seems, is mostly a set up for a pep talk. You see, Tegmark has hypothesized a universe in which one might feel random and inconsequential, and so he wants to ensure the reader that that isn’t the case so that we don’t decide to plop down and watch the world burn.

While this book is about 4/5ths pop science physics book, the other 1/5th is a memoir of Tegmark’s trials and tribulations in coloring outside the lines with his science. All and all, I think this serves the book. The author avoids coming off as whiny in the way that scientists often do when writing about their challenges in obtaining funding and / or navigating a path to tenure that is sufficiently novel but not so heterodox as to be scandalous. There’s just enough to give you the feeling that he’s suffered for his science without making him seem ungrateful or like he has a martyr complex.

Graphics are presented throughout (photos, computer renderings, graphs, diagrams, etc.), and are essential because the book deals in complex concepts that aren’t easily translated from mathematics through text description and into a layman’s visualization. The book has endnotes to expand and clarify on points, some of which are mathematical—though not all. It also has recommended reading section to help the reader expand their understanding of the subject.

I enjoyed this book and found it to be loaded with food-for-thought. If Tegmark’s vision of the universe does prove to be meritorious, it will change our approach to the world. And, if not, it will make good fodder for sci-fi.

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BOOK REVIEW: How We Feel by Giovanni Frazzetto

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How We FeelHow We Feel by Giovanni Frazzetto
My rating: 4 of 5 stars

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Frazzetto’s book tells us what neuroscience can and can’t tell us about seven core emotions: anger, guilt, anxiety, grief, empathy, joy, and love. Doing so puts the neuroscience of emotion into a broader context of art, philosophy, the humanities, and the legal / political domains. Most often this serves to make the book more interesting by offering stories beyond the case files of neurologists and neuroscience researchers, but it does result in occasional editorializing.

The book consists of seven chapters, each of which is linked to one of the emotions listed in the preceding paragraph. These chapters always tell us the rudiments of what science has learned about the brain’s role in said emotion, but they often offer insights from other disciplines as well as providing more general information about the brain that the author found particularly relevant to the topic at hand.

The first chapter delves into anger. Besides the neuroscience of rage, we learn a bit about the expression of emotion (e.g. through facial appearance; a theme revisited in other chapters), and the degree to which genetics plays a role in proclivity towards anger. This chapter serves to set up general concepts, and so we also learn about what an absence of emotion looks like (e.g. indecisiveness.) And in compliance with the law that every pop science book on neuroscience tell the story of Phineas Gage (the foreman who got rebar shot through his brain and lived to tell the story—though in an uncharacteristically hostile way), Frazzetto knocks it out early.

Chapter two explores the topic of guilt. It should be noted that some of these chapters discuss more than one related emotion, and here we learn how shame and regret are differentiated from guilt. There’s an interesting story about Caravaggio and how his own guilt-ridden story influenced one of his most famous paintings.

Chapter three is about anxiety, and also takes on fear. In addition to the neuroscience, we get a discussion of relevant philosophy, specifically that of Heidegger. Here, the author also describes brain plasticity.

The next chapter investigates grief. As I suggested above, there are multiple points where emotional expression is discussed, and this chapter has one of the most extensive of such discussions. In terms of general concepts, Frazzetto introduces the reader to neurotransmitters. One also learns how grief is related to physical pain.

Chapter five elucidates empathy. A lot of this chapter discusses acting, and the need for actors and actresses to be able to acquire empathy from the audience. The reader learns the story of Stanislavski, and how he went about creating his self-named acting system which remains widely used. This chapter also explains mirror neurons that allow one to recognize expression and to mimic others.

The penultimate chapter is about joy, and here we learn more about expression of emotions and, specifically, the seeming universality of smiles. There is a discussion of poetry as it pertains to the emotion at hand. Having introduced neurotransmitters earlier, the reader learns about dopamine, its role in happiness, and how a number of drugs have been created that increase our natural dopamine’s effect or mimic it.

The last chapter is about love. Of course, we learn about oxytocin and vasopressin, two neurochemicals famously associated with loving behavior. There is also a fascinating discussion of Capgras Syndrome. In this condition, the patient feels that his loved ones have been replaced by impostors. That may not seem relevant until one realizes that the proposed mechanism for this illness is damage to parts of the brain that control emotional connection. Without an emotional connection, the person feels that said individuals can’t be his / her dearest friends and family—though his senses register that they are exact duplicates in every way. The brain builds a rationalization that they must be impostors. Of course, no emotion evokes more resentment towards materialist explanations rooted entirely in biology than that of love.

The book is extensively annotated and also has a bibliography. There are many graphics throughout the book from line drawn diagrams of brains to photos of brain scans to the artwork “David with the Head of Goliath” mentioned relative to the discussion of Caravaggio’s guilt.

There are a number of books in this domain (i.e. the neuroscience of emotion) and if you were only going to read one, I don’t think I’d recommend this one as it. However, if you are into this topic, it is definitely worth a read. It’s interesting and insightful, and has a unique approach.

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